Rhombomere boundaries are Wnt signaling centers that regulate metameric patterning in the zebrafish hindbrain

Rhombomere boundaries and hindbrain patterning in the zebrafish

The vertebrate hindbrain is a segmented structure, divided into repeating segments called rhombomeres, at the interface of which boundary cells are induced as a specific cell type. Previous work has found that, in the zebrafish hindbrain, there is a distinctive organisation of glia and neurons along the anterior-posterior axis within each rhombomere, with specific neurons at the centre or bound...

FGF3 and FGF8 mediate a rhombomere 4 signaling activity in the zebrafish hindbrain.

The segmentation of the vertebrate hindbrain into rhombomeres is highly conserved, but how early hindbrain patterning is established is not well understood. We show that rhombomere 4 (r4) functions as an early-differentiating signaling center in the zebrafish hindbrain. Time-lapse analyses of zebrafish hindbrain development show that r4 forms first and hindbrain neuronal differentiation occurs ...

Formation and regeneration of rhombomere boundaries in the developing chick hindbrain.

Development in the chick hindbrain is founded on a segmented pattern. Groups of cells are allocated to particular segmental levels early in development, the cells of each segment (rhombomere) mixing freely with each other, but not with those of adjacent segments. After rhombomere formation, cells in the boundary regions become increasingly specialised. Rhombomeres are thus separate territories ...

Formation of regeneration of rhombomere boundaries in the developing chick hindbrain

vhnf1 and Fgf signals synergize to specify rhombomere identity in the zebrafish hindbrain.

Vertebrate hindbrain segmentation is a highly conserved process but the mechanism of rhombomere determination is not well understood. Recent work in the zebrafish has shown a requirement for fibroblast growth factor (Fgf) signaling and for the transcription factor variant hepatocyte nuclear factor 1 (vhnf1) in specification of rhombomeres 5 and 6 (r5+r6). We show here that vhnf1 functions in tw...